MSM contains several valuable properties including sulfur which is necessary for the production of collagen, glucosamine and chondroitin, all the elements that make up cartilage and connective tissues. MSM also works as a natural antioxidant. So while MSM addresses the connective tissue, HA builds and protects the synovial fluid within the joint, LubriSynHA+ with MSM is the best all in one supplement on the market to satisfy all your joint care needs.